109cTOMM701hijacks49bHLA4bindsN-CTD22vRNA2HLA2Antibody1N-NTD34N protein2847a7b66MMPP51hijacks4EAPOA112ORF3aInhibitory peptides9Antibodies224bindsNRP11SLC6A192ACE246hijacks474Spike glycoproteinPP1b4192222751,273MRM21hRNA1CMTR13mimicsvRNA4NSP1038binds94NSP16Team 2 (NSP10,14,16)vRNA133NSP15NSP104binds4NSP14hRNA1IGHMBP22UPF2 1UPF19spliceosome12AQR13mimicsvRNA3HLA1binds128NSP13 / Helicase NSP13 / Helicase Team 1 (vRTC) NSP914+vRNA15NSP7 21NSP822vRNA53168NSP12 / RdRp Polymerase Spike glycoproteinPolyprotein 1b (pp1b)Polyprotein 1b (PP1b)Polyprotein 1aPP1a7,0006,0005,000Legend: SARS-CoV-2 structural coverage map Abbreviations: 40S: small ribosomal subunit 43S: pre-initiation complex 80S: ribosome E: viral envelope protein HLA: human leukocyte antigen hRNA: host RNA M: matrix glycoprotein N: nucleocapsid protein vRNA: viral RNA vRTC: viral replication and translation complex Data sources: •The coverage map was based on Swiss-Prot sequences available on March 11, 2021. •These sequence have been aligned onto all related PDB structures available on March 27, 2021. •A total of 2,060 related structures were found. •1,180 of these structures were found from database cross-references in PDB entries. •An additional 880 related structural models were found using HHBlits with cut-offs of either E ≤ 10-10 or pairwise identity ≥ 90%.1+One structure shows binding between the two adjacent proteinsOf the above 40 structures, eight show binding to viral protein B8Viral protein B40 structures show binding to viral protein AViral protein A40Structures show binding to viral proteins, HLA, or inhibitory peptidesbindsStructures show human proteins that the viral protein may mimicmimicsStructures show viral proteins hijacking human proteinshijacksXYZName of protein domainIndicates this is part of a much larger structureOther proteins or RNAConserved residuesSheetCoilHelixSubstitutions4Number of structuresUnknown structureViral protein sequenceKnown structureTeam 2vRNA438NSP164NSP144710169Team 1 (vRTC)1+NSP134vRNA15NSP122132+1NSP121HLA34NSP8HLA1357NSP6NSP6Inhibitory peptides42binds1+3CL-Pro450NSP5NSP5NSP4C4NSP4Inhibitory peptides2binds1+UBC2UBB3UBA522ISG155hijacksPAIP11hijacksPARP1425PARP91MACROH2A22MACROH2A17MACROD24MACROD12GDAP21mimicsNAB3PL-Pro65SUD-C3SUD-M8SUD-N1Macro399Ubl14NSP3NSP240S, 43S, or 80S14hijacksCTR14NTR4NSP1Polyprotein 1a (PP1a)4,0003,0002,0001,0001